Chloroquine-induced retardation of foetal lung maturation in rats.
Identifieur interne : 002D14 ( Main/Exploration ); précédent : 002D13; suivant : 002D15Chloroquine-induced retardation of foetal lung maturation in rats.
Auteurs : A O Okanlawon [Nigeria] ; A B Ejiwunmi ; M O Dada ; O A AshiruSource :
- African journal of medicine and medical sciences [ 0309-3913 ] ; 1993.
Descripteurs français
- KwdFr :
- Animaux, Chloroquine (effets indésirables), Femelle, Hydrocortisone (pharmacologie), Maturité foetale (), Modèles animaux de maladie humaine, Mâle, Poids du corps, Poumon (), Poumon (anatomopathologie), Poumon (embryologie), Rat Sprague-Dawley, Rats, Retard de croissance intra-utérin (), Retard de croissance intra-utérin (anatomopathologie), Surfactants pulmonaires (), Taille d'organe, Échanges gazeux pulmonaires ().
- MESH :
- anatomopathologie : Poumon, Retard de croissance intra-utérin.
- effets indésirables : Chloroquine.
- embryologie : Poumon.
- pharmacologie : Hydrocortisone.
- Animaux, Femelle, Maturité foetale, Modèles animaux de maladie humaine, Mâle, Poids du corps, Poumon, Rat Sprague-Dawley, Rats, Retard de croissance intra-utérin, Surfactants pulmonaires, Taille d'organe, Échanges gazeux pulmonaires.
English descriptors
- KwdEn :
- Animals, Body Weight, Chloroquine (adverse effects), Disease Models, Animal, Female, Fetal Growth Retardation (chemically induced), Fetal Growth Retardation (pathology), Fetal Organ Maturity (drug effects), Hydrocortisone (pharmacology), Lung (drug effects), Lung (embryology), Lung (pathology), Male, Organ Size, Pulmonary Gas Exchange (drug effects), Pulmonary Surfactants (drug effects), Rats, Rats, Sprague-Dawley.
- MESH :
- chemical , adverse effects : Chloroquine.
- chemically induced : Fetal Growth Retardation.
- drug effects : Fetal Organ Maturity, Lung, Pulmonary Gas Exchange, Pulmonary Surfactants.
- embryology : Lung.
- pathology : Fetal Growth Retardation, Lung.
- chemical , pharmacology : Hydrocortisone.
- Animals, Body Weight, Disease Models, Animal, Female, Male, Organ Size, Rats, Rats, Sprague-Dawley.
Abstract
Chloroquine (CQ) is a widely used drug and its administration has been reported to increase surfactant- associated phospholipids in lungs. We have used histomorphometric techniques to study the effects of CQ on foetal lung maturation in rats. CQ (40mg/kg BW) or saline was administered to pregnant rats on days 20 and 21 of gestation. A third group received the same dose of CQ on days 20 and 21, and in addition, hydrocortisone (HD; 25 mg/kg BW) on day 21 of pregnancy. Foetuses were delivered by hysterotomy on day 22. The lungs were weighed, fixed in Bouin's fixative and embedded in paraffin. Morphometric studies were performed on 5 microns-thick sections. The lung weight/100g BW, the volume density of lung saccular spaces, and the cross-sectional area and volume of the saccular spaces were reduced but the numerical density of the saccules was not decreased in foetuses exposed to CQ. With the exception of lung weights, which were lower in the foetuses exposed to CQ and HD, there were no other differences between this group and that exposed to CQ only. The results suggest that CQ attenuates the expansion of saccular spaces which occurs in preparation for post-natal gaseous exchange, and thus CQ retards foetal lung maturation. Although HD further reduced lung weights as expected from its reported action on foetal lungs, it did not reverse the CQ-induced retardation in lung maturation.
PubMed: 7839900
Affiliations:
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uniqKey="Ashiru O" first="O A" last="Ashiru">O A Ashiru</name></author></analytic><series><title level="j">African journal of medicine and medical sciences</title><idno type="ISSN">0309-3913</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Chloroquine (adverse effects)</term><term>Disease Models, Animal</term><term>Female</term><term>Fetal Growth Retardation (chemically induced)</term><term>Fetal Growth Retardation (pathology)</term><term>Fetal Organ Maturity (drug effects)</term><term>Hydrocortisone (pharmacology)</term><term>Lung (drug effects)</term><term>Lung (embryology)</term><term>Lung (pathology)</term><term>Male</term><term>Organ Size</term><term>Pulmonary Gas Exchange (drug effects)</term><term>Pulmonary Surfactants (drug effects)</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chloroquine (effets indésirables)</term><term>Femelle</term><term>Hydrocortisone (pharmacologie)</term><term>Maturité foetale ()</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Poids du corps</term><term>Poumon ()</term><term>Poumon (anatomopathologie)</term><term>Poumon (embryologie)</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Retard de croissance intra-utérin ()</term><term>Retard de croissance intra-utérin (anatomopathologie)</term><term>Surfactants pulmonaires ()</term><term>Taille d'organe</term><term>Échanges gazeux pulmonaires ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term><term>Retard de croissance intra-utérin</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Fetal Growth Retardation</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Fetal Organ Maturity</term><term>Lung</term><term>Pulmonary Gas Exchange</term><term>Pulmonary Surfactants</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fetal Growth Retardation</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Disease Models, Animal</term><term>Female</term><term>Male</term><term>Organ Size</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Maturité foetale</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Poids du corps</term><term>Poumon</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Retard de croissance intra-utérin</term><term>Surfactants pulmonaires</term><term>Taille d'organe</term><term>Échanges gazeux pulmonaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chloroquine (CQ) is a widely used drug and its administration has been reported to increase surfactant- associated phospholipids in lungs. We have used histomorphometric techniques to study the effects of CQ on foetal lung maturation in rats. CQ (40mg/kg BW) or saline was administered to pregnant rats on days 20 and 21 of gestation. A third group received the same dose of CQ on days 20 and 21, and in addition, hydrocortisone (HD; 25 mg/kg BW) on day 21 of pregnancy. Foetuses were delivered by hysterotomy on day 22. The lungs were weighed, fixed in Bouin's fixative and embedded in paraffin. Morphometric studies were performed on 5 microns-thick sections. The lung weight/100g BW, the volume density of lung saccular spaces, and the cross-sectional area and volume of the saccular spaces were reduced but the numerical density of the saccules was not decreased in foetuses exposed to CQ. With the exception of lung weights, which were lower in the foetuses exposed to CQ and HD, there were no other differences between this group and that exposed to CQ only. The results suggest that CQ attenuates the expansion of saccular spaces which occurs in preparation for post-natal gaseous exchange, and thus CQ retards foetal lung maturation. Although HD further reduced lung weights as expected from its reported action on foetal lungs, it did not reverse the CQ-induced retardation in lung maturation.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country></list><tree><noCountry><name sortKey="Ashiru, O A" sort="Ashiru, O A" uniqKey="Ashiru O" first="O A" last="Ashiru">O A Ashiru</name><name sortKey="Dada, M O" sort="Dada, M O" uniqKey="Dada M" first="M O" last="Dada">M O Dada</name><name sortKey="Ejiwunmi, A B" sort="Ejiwunmi, A B" uniqKey="Ejiwunmi A" first="A B" last="Ejiwunmi">A B Ejiwunmi</name></noCountry><country name="Nigeria"><noRegion><name sortKey="Okanlawon, A O" sort="Okanlawon, A O" uniqKey="Okanlawon A" first="A O" last="Okanlawon">A O Okanlawon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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